About EpiQuest™ Software

EpiQuest software is a unique collection of programs, based on original algorithms, that allow analysis of a primary protein sequence.

 

This software can do something no other even claims to be able to. In particular, we can predict not only the location of potential B-epitopes, not to access their potential immunogenicity, thus predicting immunodominant epitopes. The T - epitope program currently predicts the areas of strong T-epitope location. This is a large difference from predicting some peptide that may potentially fit the MHC groove: it predicts the functionality of the epitope (works for HLA-A002 only, other haplotypes are in development).

 

The software (and we have proven this in already ongoing projects with academia and business partners and clients) can greatly streamline the development of:

  • Specific antibodies and assays

  • Combination vaccines

  • Reduction of immunogenicity for biosimilars

  • Drug development

 

We would be happy if it will helps you in your research!

EpiQuest Programs at a glance:
B-epitope prediction software

EpiQuest-B

Prediction of linear continuous B-epitopes in primary amino acid sequence of a protein. Prediction of epitope structure and immunogenicity

T-epitope mapping

EpiQuest-T

Prediction of areas containing strong T-epitope peptides in primary aminoacid sequence of a protein

acessability analysis

EpiQuest-A

Determination of accessibility/surface exposure of domains in a protein molecule.

EpiQuest-C

Evaluation of complexity (uniqueness ) of primary sequence of a protein molecule. Allows to select areas relatively unique for given type of proteins

Match

Design of complementary peptides to a given amino acid sequence.

InCharge

Sequence analysis, sequence composition, prediction of isoelectric point for protein molecules on the basis of their linear sequence.

How to start using EpiQuest Suite
News & Announcements

We thank you all for our nomination and your support!

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A  DEMO version of EpiQuest software package is available upon registeration. You can also activate your subscription to a FULL version.

Fully functional program InCharge is available FREE on our server upon registration. In Charge is to the date the most accurate program in predicting charge of proteins/peptides at different pH. 

.. and a few words about us

How we began

Philosophy

Technology

Collaborations

Aptum (and its predecessor, PickCell) has been developing own and custom antibodies since 1999. What we have found, 2000 projects later on, is that the existing B-epitope prediction software does not answer the key questions on immunogenicity of the epitope, is uniqueness, and accessibility for antibody. Actually, the most important questions, when choosing the right epitope. 6 years later we have solved at least part of these problems with our new software.

What we originally thought would be a set of tools for “in house” use in antibody development, has grown into a new approach that allows the fast and effective vaccine and biomimetic design. Our approach already allowed to find new T-cell epitopes for one critical world-wide vaccine, is used in designing of the antigens for in vitro detection on the humoral response to several pathogens, and allowed to create two non-toxic inhibitors for 2 targets for therapeutic intervention in autoimmune diseases.

Our software is based on own, unique algorithms, that are the result of many years of work. In all algorithms for main programs, the value calculated for every amino acid is based on the context, and takes into account some rules we have established for epitopes or other relevant sequences on the basis of retrospective mathematical analysis of over 50.000 of B-epitopes and over 10.000 of T-cell epitopes.

We actively work on joint development projects with a number of academia and companies worldwide, enclosing University of Southampton (UK), University of Kent (UK), London’s Institute for Tropical Medicine, and others.We are open to collaborations and are always willing to bring our expertise and technology into your research and development projects.

© 2013, 2015,2018  by APTUM BIOLOGICS LTD.